

The highest impact of booster doses against infection and death compared with full vaccination without booster doses was recorded among persons aged 50–64 and ≥65 years. When the Omicron variant emerged during December 2021, case IRRs decreased to 4.9 for fully vaccinated persons with booster doses and 2.8 for those without booster doses, relative to October–November 2021. During October–November, unvaccinated persons had 13.9 and 53.2 times the risks for infection and COVID-19–associated death, respectively, compared with fully vaccinated persons who received booster doses, and 4.0 and 12.7 times the risks compared with fully vaccinated persons without booster doses. During 2021, averaged weekly, age-standardized case IRRs among unvaccinated persons compared with fully vaccinated persons decreased from 13.9 pre-Delta to 8.7 as Delta emerged, and to 5.1 during the period of Delta predominance. To assess the impact of full vaccination with additional and booster doses (booster doses), ¶ case and death rates and incidence rate ratios (IRRs) were estimated among unvaccinated and fully vaccinated adults by receipt of booster doses during pre-Delta (April–May 2021), Delta emergence (June 2021), Delta predominance (July–November 2021), and Omicron emergence (December 2021) periods in the United States.


The SARS-CoV-2 B.1.1.529 (Omicron) variant emerged in the United States during December 2021 ( 6) and by December 25 accounted for 72% of sequenced lineages ( 7). During August–November 2021, CDC recommended § additional primary COVID-19 vaccine doses among immunocompromised persons and booster doses among persons aged ≥18 years ( 5). Previous reports of COVID-19 case, hospitalization, and death rates by vaccination status † indicate that vaccine protection against infection, as well as serious COVID-19 illness for some groups, declined with the emergence of the B.1.617.2 (Delta) variant of SARS-CoV-2, the virus that causes COVID-19, and waning of vaccine-induced immunity ( 1– 4). Scobie, PhD 1 ( View author affiliations) View suggested citation Tilakaratne, PhD 4 Kathryn Turner, PhD 23 Hailey Vest, MPH 28 Sydni Warner, MS 22 Caleb Wiedeman, MPH 25 Allison Zaldivar, MPH 27 Benjamin J. Steele, PhD 1 Meagan Stephenson, MPH 1 Allen Stout, MS 7 Kyle Strand 21 Buddhi P. Sosin, MD 13 Emma Stanislawski, MPH 13 Molly K. Casey Lyons, MPH 26 Shelby Lyons, MPH 18 Andrea May, MPH 27 Donald McCormick MSHI 9 Erica Mendoza, MAS 24 Lauren Milroy, MPH 28 Allison O’Donnell, MPH 10 Melissa Pike, MPH 11 Sargis Pogosjans, MPH 3 Amy Saupe, MPH 19 Jessica Sell, MPH 8 Elizabeth Smith, MPH 15 Daniel M. Fast, MPH 17 Ashley Gent, MPH 16 Julie Hand, MSPH 18 Dina Hoefer, PhD 14 Corinne Holtzman, MPH 19 Amanda Jara, DVM 15 Amanda Jones, MPH 20 Ishrat Kamal-Ahmed, PhD 21 Sarah Kangas, MPH 22 FNU Kanishka, MPH 21 Ramandeep Kaur, PhD 12 Saadiah Khan, MPH 6 Justice King, MSc 1 Samantha Kirkendall, MS 23 Anna Klioueva, MPH 24 Anna Kocharian, MS 22 Frances Y. Bayoumi, DrPH 6 Katherine Busen, MPH 7 Carolyn Chang, MPH 8 Mike Cima, PhD 9 Molly Crockett, MPH 10 Alicia Cronquist, MPH 11 Sherri Davidson, PhD 12 Elizabeth Davis, MA 13 Janelle Delgadillo 5 Vajeera Dorabawila, PhD 14 Cherie Drenzek, DVM 15 Leah Eisenstein, MPH 16 Hannah E. Awofeso, DVM 4 Jason Barnes, MBA 5 Nagla S. Cadwell, PhD 1 Shivani Arora, MPH 2 Tigran Avoundjian, PhD 3 Abiola O. These reports do not necessarily imply that the vaccine caused the death and often include entries not yet confirmed or verified by the government agencies.Amelia G. It is also important to note that VAERS is also open for any member of the public for submissions, alongside healthcare workers ( /reportevent.html). The CDC explains on its website that the Food and Drug Administration (FDA) requires healthcare workers to report any deaths after vaccination to VAERS (Vaccine Adverse Event Reporting System). The article’s headline reads, “CDC: 4,178 Americans DEAD Following Experimental COVID Injections – Deaths from COVID Shots now Equal 20 Years of Recorded Deaths Following Vaccines Since 2001.” However by CDC, they actually mean the government’s Vaccine Adverse Event Reporting System, or VAERS (the article is archived archive.ph/o1MRK ).

This has been corrected to state that the percentage relates to the number of doses administered.Īn article claiming that the Centers for Disease Control and Prevention (CDC) said 4,178 Americans died after receiving the COVID-19 vaccine is missing key context. Correction June 14, 2021: A previous version of this check said in paragraph eight that the figure of 0.0017% was a percentage of those who had received the vaccine.
